Trifluoroacetic acid → HCID 58899623, compound

Participants

Reaction Steps

A solution of 1,1-dimethylethyl 4-(6-{5-[(ethylamino)carbonyl]-2-methylphenyl}-1H-indazol-3-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate (Intermediate 14, 550 mg) in dichloromethane (10 ml) under nitrogen was treated dropwise with trifluoroacetic acid (0.89 ml) then stirred at room temperature for 2 h. More trifluoroacetic acid (0.89 ml) was added and stirring was continued for a further 1 h. The solvent was evaporated and the residue was dissolved in methanol and applied to an SCX ion exchange cartridge. Elution with a solution of aqueous ammonia (0.88) in methanol (10%) gave the title compound as a white solid (432 mg).

Provenance & Evidence