反应详情

Alcohol 46.5 (1.0 g, 5.7 mmol) is dissolved in anhydrous DCM (50 mL). Thionyl chloride (619 μL, 8.5 mmol) is slowly added dropwise to the solution. The resulting mixture is stirred until TLC confirms consumption of the starting material. The organic solvent is removed in vacuo. The residue is purified by column chromatography (silica, EtOAc/Hexane), to afford chloride 46.6.

1. customconsumption of the starting material
2. customThe organic solvent is removed in vacuo
3. customThe residue is purified by column chromatography (silica, EtOAc/Hexane)