HCID 59218408, compound → HCID 59218504, compound

HRID 2246684Notes

Reaction equation

HRID 2246684 reaction equation
[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:36])[CH2:15][C@@H:16]([C:22]1[CH:27]=[CH:26][C:25]([O:28]CC2C=CC=CC=2)=[CH:24][CH:23]=1)[C:17]1[CH2:21][CH2:20][O:19][N:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCO.[Pd]>[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:36])[CH2:15][C@@H:16]([C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)[C:17]1[CH2:21][CH2:20][O:19][N:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 59218408HCID 59218408, compound

Product 1

HCID 59218504HCID 59218504, compoundYield 90.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Compound 74.1 (136 mg) and a catalytic amount of Pd/C in EtOH (2 mL) was stirred at room temperature under 1 atm of H2 for 2.5 hours. The catalyst was removed by filtration, and the filtrate was concentrated to give 74.2 (100 mg). MS ESI (pos.) m/e: 395 (M+H).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-dfe4d01f8a344123b1843c64b40bb183
Source dataset
uspto-grants-2010_03
Patent number
US07687526B2

Reaction notes

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