Tert-Butylamine → N-tert. butyl-4-,5-dimethylfuran-3-sulfonamide

Participants

Reaction Steps

Analogous to the preparation of the 5-methyl-2-sulfamoyl-furan-3-carboxylic acid (see starting compound of Example 1), 2,3-dimethyl-furan [K. C. Rice and J. R. Dyer, J. Heterocycl. Chem. 12, 1325 (1975)] was converted with sulfur trioxide-pyridine complex into the 4,5-dimethyl-furan-2-sulfonic acid sodium salt and treated with phosphorus pentachloride and tert. butylamine. N-tert. butyl-4-,5-dimethyl-furan-3-sulfonamide was obtained with a yield of 34% of theory. M.p. 95°-96° C. (from petroleum ether).

Provenance & Evidence