HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2246711Generated: November 2, 2026
2-Mercaptobenzoic Acid → Ethyl 2-(4-acetamido-2-methyl-1H-indol-1-yl)acetate
https://huagongshe.com/reaction/2246711
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Mercaptobenzoic Acid | HCID 5443 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-acetic acid | HCID 66965349 | — |
| Product | Ethyl 2-(4-acetamido-2-methyl-1H-indol-1-yl)acetate | HCID 59431286 | — |
Reaction Steps
Thiosalicylic acid was added to a solution of the product from Example 1 part (iv) (474 mg) in trifluoroacetic acid (10 ml) was added thiosalicylic acid (351 mg) and the resulting suspension was heated to 60° C. for 4 hours. The mixture was concentrated in vacuo and the residue dissolved in EtOAc and washed with NaHCO3 (aq), brine, dried (MgSO4) and evaporated to give crude material. Purification by column chromatography (50% EtOAc/hexane as eluent) gave the sub-title compound (0.13 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07687535B2 |
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| Source dataset | uspto-grants-2010_03 |
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| ORD ID | ord-f0a0cca00f984f35a7fdf98d11e93854 |
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| Source note | uspto-grants-2010_03 |
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