HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Dimethylamino)acetyl chloride hydrochloride → 3-[(4-chlorophenyl)thio]-4-[[(dimethylamino)acetyl]amino]-2-methyl-1H-indole-1-acetic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Dimethylamino)acetyl chloride hydrochloride | HCID 13994991 | — |
| Reactant | 4-(acetylamino)-3-[(4-chlorophenyl)thio]-2-methyl-1H-indole-acetic acid | HCID 66965349 | — |
| Product | 3-[(4-chlorophenyl)thio]-4-[[(dimethylamino)acetyl]amino]-2-methyl-1H-indole-1-acetic acid, ethyl ester | HCID 86623608 | — |
Reaction Steps
The sub-title compound was prepared by the method of Example 1 part (iv) using the product from Example 1 part (iii) and (dimethylamino)-acetyl chloride, hydrochloride. The product was purified using column chromatography (33% EtOAc/hexane as eluent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687535B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-08d0ebdeefee4e46a330d18a7729d347 |
| Source note | uspto-grants-2010_03 |