Cyclopropylamine → HCID 68740396, compound

Participants

Reaction Steps

To a solution of (1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylic acid from Step 1 (300 mg, 1.24 mmoles) in dimethylformamide (5 mL) at room temperature was added HATU (500 mg, 1.31 mmoles) followed by cyclopropylamine (0.44 mL, 6.2 mmoles). The reaction mixture was stirred overnight and diluted with half-saturated sodium bicarbonate aqueous solution (50 mL), ether (50 mL) and ethyl acetate (50 mL). The phases were separated and the organic layer was washed with water twice (30 mL each portion), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified onto a short column of silica gel using 50% ethyl acetate diethyl ether to give the title compound.

Provenance & Evidence