Methanesulfonic Acid → HCID 86612239, compound

Participants

Reaction Steps

To a solution of N2-((1S)-1-{4′-[1-(aminocarbonyl)cyclopropyl]biphenyl-4-yl}-2,2-difluoroethyl)-N1-(1-cyanocyclopropyl)-4-fluoro-L-leucinamide (112 mg, 0.219 mmol) in THF (8 mL) was added 0.21 mL of methanesulfonic acid (1M solution in dichloromethane) followed by methyl t-butyl ether (2 mL). Seed crystals were added and the mixture was allowed to stand until a crystal bed had formed. The solvent was removed and the solid was suspended in methyl t-buty ether and heated to reflux overnight. Cooled to room temperature, filtered and dried under vacuum to give the title compound. m.p. 126 C

Provenance & Evidence