p-Toluenesulfonic acid monohydrate → HCID 86612240, compound

Participants

Reaction Steps

N1-(1-cyanocyclopropyl)-N2-[(1S)-1-(4′-{(1S,2S)-2-[(cyclopropylamino)carbonyl]cyclopropyl}biphenyl-4-yl)-2,2-difluoroethyl]-4-fluoro-L-leucinamide (60 mg, 0.11 mmol) was dissolved in 0.80 mL of THF. TsOH.H2O (21 mg, 0.11 mmol) was dissolved in 0.20 mL of THF and was added to the reaction mixture. It was stirred at room temperature for 30 minutes. Hexanes (∫3 mL) was then added until a precipitate crashed out of solution. It was sonicated for 5 minutes and it was filtered off on a Buchner funnel. The white solid was dried on the pump overnight. It was triturated in diethyl ether (˜5 mL) for 2 h at room temperature and filtered off on a Buchner funnel to yield the title compound.

Provenance & Evidence