Dimethyl Sulfoxide → HCID 11998033, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure of Example 2 starting from 2,2,2-trichloro-1-{10-[(2′-methoxy-1,1′-biphenyl-4-yl)carbonyl]-10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-3-yl}ethanone of Example 1 (0.619 g, 1.15 mmole), (4-benzyl-1,4-oxazinan-2-yl)-methylamine (01.97 g, 0.955 mmole), dimethylsulfoxide (0.374 g, 4.8 mmole), and triethylamine (0.213 g, 2.1 mmole) in 15 mL of acetonitrile. The residue was adsorbed on silica Merck-60 and purified by flash chromatography (0-75% ethyl acetate in dichloromethane) to provide an off white solid (0.241 g), m.p. 180-182° C.

Provenance & Evidence