Melanin-concentrating hormone → n-{4-[2-{3-[(1e)-Hex-1-en-1-yl]phenyl}-2-(1h-indol-3-yl)-1-methylethyl]benzoyl}-beta-alanine

Participants

Reaction Steps

The title compound was prepared from the intermediate from Step A using the hydrolysis conditions described in INTERMEDIATE 2, Step G. The crude material was purified by HPLC. 1H NMR (500 MHz, CD3CN): δ 8.97 (s, 1H); 7.55 (d, J=8.3 Hz, 2H); 7.52 (d, J=7.9 Hz, 1H); 7.49 (s, 1H); 7.43 (d, J=8.3 Hz, 2H); 7.33 (d, J=7.5 Hz, 1H); 7.20 (t, J=7.6 Hz, 2H); 7.14 (m, 2H); 7.07 (broad s, 1H); 6.99-6.96 (m, 1H); 6.92-6.89 (m, 1H); 6.40-6.25 (m, 2H); 4.50 (d, J=11.5 Hz, 1H); 3.77-3.69 (m, 1H); 3.49 (q, J=6.4 Hz, 2H); 2.53 (dd, J=14.4, 21.1 Hz, 26H); 1.47-1.33 (m, 4H); 1.08 (d, J=6.8 Hz, 3H); 0.92 (t, J=7.2 Hz, 3H). LC1 3.72 min. (M+1)=509.

Provenance & Evidence