Hydrochloric Acid → HCID 11681207, compound

Participants

Reaction Steps

A solution of KOH (30 mg, 0.54 mmol) in 30% H2O2 (2 mL) was added to a solution of Example 23 (80 mg, 0.27 mmol) in methanol (6 mL) at r.t. After stirring for 16 h, the solution was neutralized with 1N HCl and concentrated in vacuo. Purification by Prep-HPLC yielded 58 mg (50%) of the title compound as a white solid. 1H NMR (400 MHz, MeOD-d4): δ 9.19 (s, 1H), 8.10 (s, 1H), 7.43-7.60 (m, 4H), 4.41 (qAB, 2H, J=158.8, 14.8 Hz), 4.32 (s, 3H). MS (ES) [m+H] calc'd for C16H15N4OCl, 315, 317; found 315, 317.

Provenance & Evidence