Potassium Phosphate, Tribasic → HCID 68442404, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2.75 g of 6-oxo-4-(toluene sulfonyloxy)-3,6-dihydro-2H-pyridine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester in 18 ml of tetrahydrofuran are added 1.4 g of 4-methoxyphenylboronic acid, 3.15 g of potassium phosphate, 0.12 g of ′ic′cl′hexyl-(2′,4′,6′-triisopropyl-biphenyl-2-yl)-phosphane (X-PHOS) and 22 mg of palladium acetate under argon. The reaction mixture is heated to 80° C. for 2 hours, cooled to room temperature, diluted with ethyl acetate and the organic phase is washed with water and dried over sodium sulfate. The residue is purified by flash chromatography (SiO2 60 F) to afford the title compound as a brown solid. Rf=0.35 (EtOAc-heptane 1:2); Rt=4.95.

Provenance & Evidence