Methyl butyrate → HCID 68440878, compound

HRID 2246984Notes

Reaction equation

Br[CH2:2][C@H:3]1[NH:8][CH2:7][C@H:6]([O:9][CH:10]([C:21]2[CH:22]=[CH:23][C:24]3[O:29][CH2:28][CH2:27][N:26]([CH2:30][CH2:31][CH2:32][O:33][CH3:34])[C:25]=3[CH:35]=2)S(C2C=CC(C)=CC=2)(=O)=O)[C@@H:5]([C:36]2[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[CH:38][CH:37]=2)[CH2:4]1.[C:44]([O:49][CH3:50])(=[O:48])[CH2:45][CH2:46][CH3:47]>>[CH3:50][O:49][C:44](=[O:48])[CH:45]([CH2:2][C@@H:3]1[CH2:4][C@H:5]([C:36]2[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[CH:38][CH:37]=2)[C@@H:6]([O:9][CH2:10][C:21]2[CH:22]=[CH:23][C:24]3[O:29][CH2:28][CH2:27][N:26]([CH2:30][CH2:31][CH2:32][O:33][CH3:34])[C:25]=3[CH:35]=2)[CH2:7][NH:8]1)[CH2:46][CH3:47]

Participants

Reactant 2

HCID 12180Methyl butyrate

HCID 68441937HCID 68441937, compound

Product 1

HCID 68440878HCID 68440878, compound

Procedure

According to example 65c, 6-[(3R,4R,6S)-6-bromomethyl-4-(4-methoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidin-3-yloxymethyl]-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine (from example 65d) and methyl butyrate are used to afford the title compound which is identified based on its Rf values.

Sources & evidence

ORD record: ord-b983db511821414187816995716f7b4f
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07687495B2

Reaction notes

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