HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 11394934, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | HCID 11750153 | HCID 11750153 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 11394934 | HCID 11394934 | 67% |
Reaction Steps
The title compound was prepared by reacting (S)-N-{3-[4-(4-fluoro-4-azidomethylpiperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (0.73 mmol) with triphenylphosphine (1.27 mmol) in tetrahydrofuran (10 ml) at a temperature 25° C. for six hours and then refluxing for overnight after addition of drop of water followed by purification using silica gel column chromatography in 67% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687627B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-2786c827f1284eb3ab1c9ba475406bf4 |
| Source note | uspto-grants-2010_03 |