HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 11383720, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | HCID 11382912 | HCID 11382912 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 11383720 | HCID 11383720 | 51% |
Reaction Steps
The title compound was prepared by reacting (S)-N-{3-[4-(1-oxa-6-aza-spiro[2.5]oct-6-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (18.0 mmol) and potassium cyanide (22.0 mmol) in methanol: dimethylformamide mixture (1:5, 20 ml) at a temperature 25° C. for 14 hours and by purifying the compound by silica gel column chromatography in 51% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687627B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-14a4f32777af424ba9f0ddd5eac502c8 |
| Source note | uspto-grants-2010_03 |