HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → (S)-N-{3-[4-(4-Aminocarbonyl-4-hydroxypiperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | (S)-N-{3-[4-(4-cyano-4-hydroxypiperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide | HCID 11394757 | — |
| Product | (S)-N-{3-[4-(4-Aminocarbonyl-4-hydroxypiperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide | HCID 11383840 | 62% |
Reaction Steps
The compound was obtained by reacting (S)-N-{3-[4-(4-cyano-4-hydroxypiperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (12 mmol) with 95% aqueous sulfuric acid at a temperature 25° C. for 14 hours and purifying the compound by silica gel column chromatography in 62% yield. M.P. 238-40° C. and MS (M+1)=395 (MH+, 100%) for M.F.=C18H23FN4O5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687627B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-d7d0fad1d38643f280c77466104d14c4 |
| Source note | uspto-grants-2010_03 |