Dimethylamine → HCID 68694125, compound

HRID 2247026Notes

Reaction equation

HRID 2247026 reaction equation
[O:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]4=[O:25])=[CH:11][C:10]=3[F:26])[CH2:5][CH2:4]2)[CH2:2]1.[CH3:27][NH:28][CH3:29]>CO>[CH3:27][N:28]([C:3]1([OH:1])[CH2:4][CH2:5][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]3=[O:25])=[CH:11][C:10]=2[F:26])[CH:7]([CH3:8])[CH2:2]1)[CH3:29]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 11382912HCID 11382912, compound

Product 1

HCID 68694125HCID 68694125, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound was prepared by reacting (S)-N-{3-[4-(1-oxa-6-aza-spiro[2.5]oct-6-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (1.37 mmol) with 40% aqueous solution dimethylamine (1.72 mmol) in methanol (10 ml) at a temperature 25° C. for 14 hours and by purifying the compound by silica gel column chromatography in 70% yield.

Workup

  1. customat a temperature 25° C.
  2. customfor 14 hours
  3. customby purifying the compound by silica gel column chromatography in 70% yield

Sources & evidence

ORD record
ord-de870d67da0f4d31bb487d50d5ef972a
Source dataset
uspto-grants-2010_03
Patent number
US07687627B2

Reaction notes

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