Lawesson's reagent → HCID 11375922, compound

HRID 2247050Notes

Reaction equation

HRID 2247050 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2([C:36]#[N:37])[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][C:21]([N:24]4[CH2:28][C@H:27]([CH2:29][NH:30][C:31](=O)[CH3:32])[O:26][C:25]4=[O:34])=[CH:20][C:19]=3[F:35])[CH2:14][CH2:13]2)=[CH:7][CH:6]=1)=[O:4].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:47])=CC=1>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2([C:36]#[N:37])[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][C:21]([N:24]4[CH2:28][C@H:27]([CH2:29][NH:30][C:31](=[S:47])[CH3:32])[O:26][C:25]4=[O:34])=[CH:20][C:19]=3[F:35])[CH2:14][CH2:13]2)=[CH:7][CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 11752559HCID 11752559, compound

Product 1

HCID 11375922HCID 11375922, compoundYield 61%

Procedure

By using procedure as described in Example 82 and by reacting (S)-N-{3-[4-(4-(4-methoxycarbonylphenylamino)-4-cyanopiperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide and Lawesson's reagent the compound was obtained in 61% yield.

Workup

  1. customwas obtained in 61% yield

Sources & evidence

ORD record
ord-a4005807afcc49a6bc9411969e233eae
Source dataset
uspto-grants-2010_03
Patent number
US07687627B2

Reaction notes

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