HCID 11463102, compound → HCID 11373155, compound

HRID 2247058Notes

Reaction equation

HRID 2247058 reaction equation
[S:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]4=[O:25])=[CH:11][C:10]=3[F:26])[CH2:5][CH2:4]2)[CH2:2]1.I([O-])(=O)(=O)=O.[Na+].[OH2:33].[CH3:34]O>>[S:1](=[C:2]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]4=[O:25])=[CH:11][C:10]=3[F:26])[CH2:5][CH2:4]2)[CH2:34]1)=[O:33]

Participants

4

Reactant 3

HCID 11463102HCID 11463102, compoundHCID 22242641Methanol--water (1/1)HCID 23667635Sodium periodate

Product 1

HCID 11373155HCID 11373155, compoundYield 57%

Procedure

The title compound was prepared by reacting (S)-N-{3-[4-(1-thia-6-aza-spiro[2.5]oct-6-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (0.4 mmol) and sodium periodate (mmol) in methanol water mixture (10 ml) at a temperature 25-30° C. for 14 hours in 57% yield.

Workup

  1. customat a temperature 25-30° C.
  2. customfor 14 hours

Sources & evidence

ORD record
ord-ab0c57437aa94611b8003b58bf6b9388
Source dataset
uspto-grants-2010_03
Patent number
US07687627B2

Reaction notes

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