3-Mercaptopropanol → HCID 11223575, compound

HRID 2247065Notes

Reaction equation

HRID 2247065 reaction equation
[O:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]4=[O:25])=[CH:11][C:10]=3[F:26])[CH2:5][CH2:4]2)[CH2:2]1.OCC[CH2:30][SH:31]>>[O:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:19][C@H:18]([CH2:20][NH:21][C:22](=[O:24])[CH3:23])[O:17][C:16]4=[O:25])=[CH:11][C:10]=3[F:26])[CH2:5][CH2:4]2)[CH2:30][S:31][CH2:2]1

Participants

3

Reactant 2

HCID 882113-MercaptopropanolHCID 11382912HCID 11382912, compound

Product 1

HCID 11223575HCID 11223575, compound

Procedure

The title compound was prepared by reacting (S)-N-{3-[4-(1-oxa-6-aza-spiro[2.5]oct-6-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide (0.275 mmol) and 3-hydroxypropanethiol (mmol) in at a temperature ° C. for hours in % yield. Mp; 114-116° C., Mass m/z 424.1 (ES+, 100%) for C20H26FN3O4S.

Workup

  1. waitfor hours in % yield

Sources & evidence

ORD record
ord-f09c74e42aa74ee08754f73cb1300ef7
Source dataset
uspto-grants-2010_03
Patent number
US07687627B2

Reaction notes

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