Acetonitrile → sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

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Reaction Steps

In a 100 ml flask were placed fluvastatin methyl ester (2.42 g), EtOH (5 ml) and a solution of NaOH (0.23 g) in EtOH (7 ml). The mixture was stirred at reflux for 2.5 h and acetonitrile (50 ml) was added. The slurry was stirred at reflux for another 3 h then cooled to room temperature and stirred over night. The product was isolated by filtration under nitrogen and dried at 50EC in a vacuum oven for 24 h to obtain 2.02 g (83%) of fluvastatin sodium crystal Form XLVI.

Provenance & Evidence