Sodium Hydroxide → sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

Participants

Reaction Steps

Fluvastatin methyl ester (3.0 g) was dissolved in acetone (45 ml) and a solution of NaOH (0.36 g) in MeOH (5 ml) was added. After 3 h NaOH (0.072 g) was added and the mixture was stirred at room temperature for another 21 h. NaOH (0.073 g) was added and the mixture was stirred for another 4 h. The product was isolated by filtration under nitrogen, washed with acetone (55 ml) and dried at 50EC in a vacuum oven for 24 h to obtain 2.64 g of fluvastatin sodium crystal Form LXVII.

Provenance & Evidence