Sodium Hydroxide → sodium;(E)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate

Participants

Reaction Steps

A 100 ml round bottom flask was loaded with Fluvastatin methyl ester (3.0 g, 7.08 mmole), water (30 ml) and NaOH (0.29 g). The mixture was stirred for 3 h at room temperature then extracted with ethyl acetate (30 ml). The aqueous solution was evaporated, acetonitrile (12 ml) was added and the mixture was stirred at room temperature over night. The product was isolated by filtration under nitrogen flow, washed with acetonitrile (20 ml) and dried at 40EC in a vacuum oven for 24 h to obtain 0.37 g (12%) of fluvastatin sodium crystal Form LXXVIII.

Provenance & Evidence