1-Boc-2-(3-amino-5-trifluoromethyl-phenoxymethyl)-pyrrolidine → 1-Boc-2-[3-[(2-Fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxymethyl}-pyrrolidine

HRID 2247171Notes

Reaction equation

HRID 2247171 reaction equation
[C:1]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][O:14][C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([NH2:25])[CH:16]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].C(N1CCC(OC2C=C(C(F)(F)F)C=C(N[C:51]([C:53]3[C:54]([F:59])=[N:55][CH:56]=[CH:57][CH:58]=3)=[O:52])C=2)CC1)(OC(C)(C)C)=O>>[C:1]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][O:14][C:15]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([NH:25][C:51]([C:53]2[C:54]([F:59])=[N:55][CH:56]=[CH:57][CH:58]=2)=[O:52])[CH:16]=1)([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2]

Participants

3

Reactant 2

HCID 219594881-Boc-2-(3-amino-5-trifluoromethyl-phenoxymethyl)-pyrrolidineHCID 219595211-Boc-4-[3-[(2-fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine

Product 1

HCID 219595771-Boc-2-[3-[(2-Fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxymethyl}-pyrrolidine

Procedure

1-Boc-2-{3-[(2-Fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxymethyl}-pyrrolidine was prepared from 1-Boc-2-(3-amino-5-trifluoromethyl-phenoxymethyl)-pyrrolidine by a procedure similar to that described in the preparation of 1-Boc-4-{3-[(2-fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine.

Sources & evidence

ORD record
ord-e583335d8beb435da509b8c533a7c8b7
Source dataset
uspto-grants-2010_03
Patent number
US07687643B2

Reaction notes

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