1-Boc-4-(3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine → N-[4-tert-Butyl-3-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-2-chloro-nicotinamide

HRID 2247187Notes

Reaction equation

HRID 2247187 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][C:6]=1[O:12][CH2:13][CH:14]1[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]1)([CH3:4])([CH3:3])[CH3:2].C(N1CCC(OC2C=C(C(F)(F)F)C=C(N[C:46]([C:48]3[C:49]([Cl:54])=[N:50][CH:51]=[CH:52][CH:53]=3)=[O:47])C=2)CC1)(OC(C)(C)C)=O>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:46](=[O:47])[C:48]2[CH:53]=[CH:52][CH:51]=[N:50][C:49]=2[Cl:54])=[CH:7][C:6]=1[O:12][CH2:13][CH:14]1[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 219596471-Boc-4-(3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidineHCID 666885054-Tert-butyl-3-(1-methyl-piperidin-4-ylmethoxy)-phenylamine

Product 1

HCID 86586069N-[4-tert-Butyl-3-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-2-chloro-nicotinamide

Procedure

N-[4-tert-Butyl-3-(1-methyl-piperidin-4-ylmethoxy)-phenyl]-2-chloro-nicotinamide was prepared from 4-tert-butyl-3-(1-methyl-piperidin-4-ylmethoxy)-phenylamine by a procedure similar to that described in the preparation of 1-Boc-4-{3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine.

Sources & evidence

ORD record
ord-734874cb8bd445abbf64bfea2e9867e1
Source dataset
uspto-grants-2010_03
Patent number
US07687643B2

Reaction notes

Loading…