1-Tert-butyl 4-ethyl piperidine-1,4-dicarboxylate → Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

HRID 2247189Notes

Reaction equation

HRID 2247189 reaction equation
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)=O)C.N1(C(C)CO)CCOCC1>>[C:12]([N:9]1[CH2:10][CH2:11][CH:6]([CH2:4][OH:3])[CH2:7][CH2:8]1)([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13]

Participants

3

Reactant 2

HCID 27588121-Tert-butyl 4-ethyl piperidine-1,4-dicarboxylateHCID 109863712-morpholin-4-ylpropan-1-ol

Product 1

HCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

Procedure

1-Boc-4-Hydroxymethyl-piperidine was prepared from 1-Boc-piperidine-4-carboxylic acid ethyl ester by a procedure similar to that described in the preparation of 2-morpholin-4-yl-propanol.

Sources & evidence

ORD record
ord-563595c6db3343b1bceaa979fafac63e
Source dataset
uspto-grants-2010_03
Patent number
US07687643B2

Reaction notes

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