2-Chloronicotinoyl chloride → 2-Chloro-N-[3-(2-pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenyl]-nicotinamide

HRID 2247195Notes

Reaction equation

HRID 2247195 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH2:19])[CH:12]=[CH:13][C:14]=2[C:15]([F:18])([F:17])[F:16])[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:20][C:21]1[C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=[CH:23][N:22]=1.C(N1CCC(OC2C=C(C(F)(F)F)C=C(NC(C3C(Cl)=NC=CC=3)=O)C=2)CC1)(OC(C)(C)C)=O>>[Cl:20][C:21]1[N:22]=[CH:23][CH:24]=[CH:25][C:26]=1[C:27]([NH:19][C:11]1[CH:12]=[CH:13][C:14]([C:15]([F:17])([F:18])[F:16])=[C:9]([O:8][CH2:7][CH2:6][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:10]=1)=[O:28]

Participants

4

Reactant 3

HCID 27745412-Chloronicotinoyl chlorideHCID 219594573-(2-Pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenylamineHCID 219596471-Boc-4-(3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine

Product 1

HCID 219593482-Chloro-N-[3-(2-pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenyl]-nicotinamide

Procedure

2-Chloro-N-[3-(2-pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenyl]-nicotinamide was prepared from 3-(2-pyrrolidin-1-yl-ethoxy)-4-trifluoromethyl-phenylamine and 2-chloropyridine-3-carbonyl chloride by a procedure similar to that described in the preparation of 1-Boc-4-{3-[(2-chloro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxy}-piperidine.

Sources & evidence

ORD record
ord-5cd5ce471bfa48c691bb49ae21c69783
Source dataset
uspto-grants-2010_03
Patent number
US07687643B2

Reaction notes

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