Trifluoroacetic acid → HCID 22498893, compound

Participants

Reaction Steps

2.5 ml of TFA was added to a solution of 7-({2-[(5-fluoro-pyridin-2-ylmethyl)-amino]-pyridine-3-carbonyl}-amino)-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (0.20 g, 0.40 mmol) in 2.5 ml of CH2Cl2. The mixture was stirred at RT for 1 h. The volatiles were removed under reduced pressure, and the residue was purified by flash column chromatography (2 to 5% of MeOH in CH2Cl2 with 2% of NH4OH). The titled compound was obtained as an off-white solid. MS: (ES+) 406.1 (M+H). Calc'd. for C23H24FN5O—405.47.

Provenance & Evidence