4-Tert-Butylaniline → HCID 85890745, compound

Participants

Role	Name	HCID	Charge
Reactant	4-Tert-Butylaniline	HCID 69861	—
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	3,6-Dichloropyridazine-4-carboxylic acid	HCID 433804	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 85890745	HCID 85890745	—

Reaction Steps

3,6-Dichloro-pyridazine-4-carboxylic acid (1.93 g, 10 mmol), 4-tert-Butyl-phenylamine (1.49 g, 10 mmol), DIEA (3.5 mL, 20 mmol), and HATU (4.56 g, 12 mmol) were added to DMF (20 mL). The reaction was stirred at rt for 15 h. The resulting dark brown solution was extracted with DCM (2×10 mL), washed with H2O (2×10 mL), and dried over sodium sulfate. The curde product was further purified using Flash Chromatography (2% MeOH/DCM), affording the desired product as yellow solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07687643B2
Source dataset	uspto-grants-2010_03
ORD ID	ord-148bab1818284088b13ac7b9c80585a3
Source note	uspto-grants-2010_03