HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetylthiourea → N-[5-(4-Methoxy-3-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetylthiourea | HCID 2723593 | — |
| Reactant | 5-(1-Bromo-2-oxopropyl)-2-methoxybenzene-1-sulfonamide | HCID 71366918 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[5-(4-Methoxy-3-sulfamoyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide | HCID 86598407 | — |
Reaction Steps
5-(1-Bromo-2-oxo-propyl)-2-methoxy-benzenesulfonamide (Example 30b) (0.2 g, 0.64 mmol) and N-acetylthiourea (0.075 g, 0.64 mmol) in ethanol (3 ml) are stirred at 70° C. for 4 hours. The mixture is concentrated and the residue is recrystallised from ethanol to give an off-white solid. MH+ (ESMS): Mp 341.9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687637B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-703870973dd34ffe886da31a9303cd7e |
| Source note | uspto-grants-2010_03 |