Sodium Hydroxide → HCID 86598410, compound

HRID 2247345Notes

Reaction equation

HRID 2247345 reaction equation
[OH-].[Na+].C([O:5][C:6](=[O:28])[CH2:7][NH:8][C:9]([NH:11][C:12]1[S:13][C:14]([C:18]2[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][CH:19]=2)=[C:15]([CH3:17])[N:16]=1)=[O:10])C>CO>[CH3:27][S:24]([C:21]1[CH:22]=[CH:23][C:18]([C:14]2[S:13][C:12]([NH:11][C:9](=[O:10])[NH:8][CH2:7][C:6]([OH:28])=[O:5])=[N:16][C:15]=2[CH3:17])=[CH:19][CH:20]=1)(=[O:25])=[O:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86598411HCID 86598411, compound

Product 1

HCID 86598410HCID 86598410, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Aqueous sodium hydroxide (2M, 0.5 ml) is added to a stirred solution of {3-[5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-ureido}-acetic acid ethyl ester (Example 60) (0.14 g, 0.00035 mmol) in methanol (2 ml). After stirring at room temperature for 18 hours the solvent is removed and dilute HCl is added. The resulting yellow solid is removed by filtration and recrystallised from ethanol to afford the title compound. MH+ 370.0

Workup

  1. customis removed
  2. additiondilute HCl is added
  3. customThe resulting yellow solid is removed by filtration
  4. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-1bffd8ce5e154e27b547de54b65d8a74
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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