HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86598415, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Tetrazolylacetic acid | HCID 543207 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 57473751 | HCID 57473751 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86598415 | HCID 86598415 | — |
Reaction Steps
5-(4-Methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Example 58) (0.08 g, 0.3 mmol) is added to a solution of HATU (0.113 g, 0.3 mmol) and 1-tetrazole acetic acid (0.039 g, 0.31 mmol) in DCM. Triethylamine (0.104 ml, 0.75 mmol) is then added and the reaction mixture is left to stir at room temperature overnight. The product is purified by chromatography on silica eluting with methanol—DCM (96:4) to give the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687637B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-fbc1b5656c0f458cb9436af848db5656 |
| Source note | uspto-grants-2010_03 |