反应详情

温度

140 °C

A stirred mixture of N-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Example 64) (0.1 g, 0.30 mmol), imidazole (0.069 g, 0.90 mmol) and caesium carbonate (0.198 g, 0.60 mmol) in dry DMSO is heated under argon at 140° C. for 2 hours. The solvent is removed and water (30 ml) is added. The product is extracted with ethyl acetate (2×30 ml) and the combined organic extracts are washed with brine (20 ml) and dried (MgSO4). Removal of the solvent and trituration with methanol affords the titled compound as an orange solid. MH+: 377.9721

1. customThe solvent is removed
2. additionwater (30 ml) is added
3. extractionThe product is extracted with ethyl acetate (2×30 ml)
4. washthe combined organic extracts are washed with brine (20 ml)
5. dry with materialdried (MgSO4)
6. customRemoval of the solvent and trituration with methanol