Thiourea → 5-[4-Chloro-3-(methylsulfonyl)phenyl]-4-methyl-1,3-thiazol-2-amine

HRID 2247359Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([NH:13]C(=O)C)=[N:10][C:9]=2[CH3:17])=[CH:4][C:3]=1[S:18]([CH3:21])(=[O:20])=[O:19].NC(N)=S>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][C:11]([NH2:13])=[N:10][C:9]=2[CH3:17])=[CH:4][C:3]=1[S:18]([CH3:21])(=[O:19])=[O:20]

Participants

Reactant 2

HCID 2723790Thiourea

HCID 57831148N-[5-(4-Chloro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide

Product 1

HCID 578311165-[4-Chloro-3-(methylsulfonyl)phenyl]-4-methyl-1,3-thiazol-2-amine

Procedure

This compound is made via an analogous procedure to N-[5-(4-Chloro-3-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide (Ex. 48) by replacing N-acetylthiourea with thiourea.

Sources & evidence

ORD record: ord-02936bb99d9b4ba58f55246f7df2d223
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07687637B2

Reaction notes

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