Thiourea → 4-Methyl-5-(3-nitro-phenyl)-thiazol-2-ylamine

HRID 2247365Notes

Reaction equation

HRID 2247365 reaction equation
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1)[C:3](=O)[CH3:4].[NH2:15][C:16]([NH2:18])=[S:17]>C(O)C>[CH3:4][C:3]1[N:15]=[C:16]([NH2:18])[S:17][C:2]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 85861734HCID 85861734, compound

Product 1

HCID 183229114-Methyl-5-(3-nitro-phenyl)-thiazol-2-ylamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

A stirred solution of 1-Bromo-1-(3-nitro-phenyl)-propan-2-one (98a) (2.4 g, 9.3 mmol) in ethanol (20 ml) at room temperature is treated with thiourea (0.71 g, 9.3 mmol). The reaction mixture is heated to 70° C. for 10 minutes. The resulting precipitate is removed by filtration and dried under vacuum to give the titled compound.

Workup

  1. customThe resulting precipitate is removed by filtration
  2. customdried under vacuum

Sources & evidence

ORD record
ord-f76bb2a19363427b8e41b71050e3a3cf
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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