3-Aminopropionitrile → 1-(2-Cyano-ethyl)-3-[5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea

Participants

Role	Name	HCID	Charge
Reactant	3-Aminopropionitrile	HCID 1647	—
Reactant	5-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amine	HCID 57351277	—
Reactant	Imidazole-1-carboxylic acid [5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-amide	HCID 86598422	—
Product	1-(2-Cyano-ethyl)-3-[5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea	HCID 86598423	—

Reaction Steps

The titled compound is prepared by the same procedure as example 88, replacing 2-aminoethanol (part 88b) in this example with 3-aminopropionitrile and replacing 5-(3-fluoro-4-methanesulfonyl-phenyl)-2-isocyanato-4-methyl-thiazole (88a) with Imidazole-1-carboxylic acid [5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-amide (150a)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07687637B2
Source dataset	uspto-grants-2010_03
ORD ID	ord-426cbbdc70644aa89b90472886ea3c5b
Source note	uspto-grants-2010_03