Acetylthiourea → HCID 85861692, compound

HRID 2247374Notes

Reaction equation

HRID 2247374 reaction equation
Br[CH:2]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[C:8]([O:13][CH3:14])[CH:7]=1)[C:3](=O)[CH3:4].[C:15]([NH:18][C:19]([NH2:21])=[S:20])(=[O:17])[CH3:16]>C(O)C>[F:12][C:9]1[CH:10]=[CH:11][C:6]([C:2]2[S:20][C:19]([NH:18][C:15](=[O:17])[CH3:16])=[N:21][C:3]=2[CH3:4])=[CH:7][C:8]=1[O:13][CH3:14]

Participants

4

Reactant 2

HCID 2723593AcetylthioureaHCID 85861651HCID 85861651, compound

Product 1

HCID 85861692HCID 85861692, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

1-Bromo-1-(4-fluoro-3-methoxy-phenyl)-propan-2-one (161b) (0.72 g, 2.74 mmol) is dissolved in ethanol (20 ml) and N-acetylthiourea (0.324 g, 2.72 mmol) is added in one portion. The mixture is stirred at 80° C. overnight then allowed to cool whereupon the product crystallised. Filtration affords the title compound as a white solid.

Workup

  1. temperatureto cool whereupon the product
  2. customcrystallised
  3. filtrationFiltration

Sources & evidence

ORD record
ord-eeccb7c18f074b92baf0d36afe70d2a0
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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