Ethyl 3-isocyanatopropanoate → HCID 86598432, compound

HRID 2247381Notes

Reaction equation

HRID 2247381 reaction equation
C(OC(=O)CC[CH2:7][NH:8][C:9]([NH:11][C:12]1[S:13][C:14]([C:18]2[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[C:20]([F:28])[CH:19]=2)=[C:15]([CH3:17])[N:16]=1)=[O:10])C.[CH2:30]([O:32][C:33](=[O:39])[CH2:34]CN=C=O)[CH3:31]>>[CH2:30]([O:32][C:33](=[O:39])[CH2:34][CH2:7][NH:8][C:9]([NH:11][C:12]1[S:13][C:14]([C:18]2[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[C:20]([F:28])[CH:19]=2)=[C:15]([CH3:17])[N:16]=1)=[O:10])[CH3:31]

Participants

3

Reactant 2

HCID 2733373Ethyl 3-isocyanatopropanoateHCID 865984314-{3-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-ureido)-butyric acid ethyl ester

Product 1

HCID 86598432HCID 86598432, compound

Procedure

The title compound is prepared by the same procedure as 4-{3-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-ureido}-butyric acid ethyl ester (Example 164) by replacing ethyl-4-isocyanatobutyrate with 3-isocyanato-propionic acid ethyl ester.

Sources & evidence

ORD record
ord-124fa1039435415897ec99f0159c20f2
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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