5-(3-Imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine → 4-{3-[5-(3-Imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-ureido}-butyric acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:29])[CH2:5][CH2:6][CH2:7][NH:8][C:9]([NH:11][C:12]1[S:13][C:14]([C:18]2[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[C:20](F)[CH:19]=2)=[C:15]([CH3:17])[N:16]=1)=[O:10])[CH3:2].[N:30]1(C2C=C(C3SC(N)=NC=3C)C=CC=2S(C)(=O)=O)[CH:34]=[CH:33][N:32]=[CH:31]1>>[CH2:1]([O:3][C:4](=[O:29])[CH2:5][CH2:6][CH2:7][NH:8][C:9]([NH:11][C:12]1[S:13][C:14]([C:18]2[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[C:20]([N:30]3[CH:34]=[CH:33][N:32]=[CH:31]3)[CH:19]=2)=[C:15]([CH3:17])[N:16]=1)=[O:10])[CH3:2]Participants
3
Reactant 2
Product 1
Procedure
The title compound is prepared by the same procedure as 4-{3-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-ureido}-butyric acid ethyl ester (Example 164) by replacing 5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Example 72) with 5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Example 148).
Sources & evidence
- ORD record
- ord-39c62cf81d8a4de88231c76d27bb7c28
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07687637B2
Reaction notes
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