Thiourea → 5-(3-Methanesulphonyl-phenyl)-4-methyl-thiazol-2-ylamine hydrobromide

HRID 2247399Notes

Reaction equation

HRID 2247399 reaction equation
[Br:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:7]=1)[C:3](=O)[CH3:4].[NH2:16][C:17]([NH2:19])=[S:18]>>[BrH:1].[CH3:15][S:12]([C:8]1[CH:7]=[C:6]([C:2]2[S:18][C:17]([NH2:19])=[N:16][C:3]=2[CH3:4])[CH:11]=[CH:10][CH:9]=1)(=[O:14])=[O:13]

Participants

3

Reactant 2

HCID 2723790ThioureaHCID 858616531-Bromo-1-(3-methanesulphonyl-phenyl)-propanone

Product 1

HCID 865984455-(3-Methanesulphonyl-phenyl)-4-methyl-thiazol-2-ylamine hydrobromide

Procedure

A stirred solution of 1-bromo-1-(3-methanesulphonyl-phenyl)-propanone (176c) (0.32 g, 1.01 mmol) is treated with thiourea (0.067 g, 0.88 mmol) added in one portion. The reaction mixture is allowed to stir at room temperature over two days. The product precipitates out and is filtered to yield the title compound as while solid.

Workup

  1. additionadded in one portion
  2. customThe product precipitates out
  3. filtrationis filtered

Sources & evidence

ORD record
ord-59f736901d8149fba120e1317130c35c
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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