5-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amine → Imidazole-1-carboxylic acid [5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-amide

HRID 2247401Notes

Reaction equation

HRID 2247401 reaction equation
N1([C:6]2[CH:7]=[C:8]([C:16]3[S:20][C:19]([NH:21][C:22]([N:24]4[CH:28]=[CH:27][N:26]=[CH:25]4)=[O:23])=[N:18][C:17]=3[CH3:29])[CH:9]=[CH:10][C:11]=2[S:12]([CH3:15])(=[O:14])=[O:13])C=CN=C1.[F:30]C1C=C(C2SC(N)=NC=2C)C=CC=1S(C)(=O)=O>>[F:30][C:6]1[CH:7]=[C:8]([C:16]2[S:20][C:19]([NH:21][C:22]([N:24]3[CH:28]=[CH:27][N:26]=[CH:25]3)=[O:23])=[N:18][C:17]=2[CH3:29])[CH:9]=[CH:10][C:11]=1[S:12]([CH3:15])(=[O:14])=[O:13]

Participants

3

Reactant 2

HCID 573512775-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amineHCID 86598422Imidazole-1-carboxylic acid [5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-amide

Product 1

HCID 71480199Imidazole-1-carboxylic acid [5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-amide

Procedure

The title compound is prepared by the same procedure as imidazole-1-carboxylic acid [5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-amide (Example 150a) by replacing 5-(3-imidazol-1-yl-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Example 148) with 5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (Example 72)

Sources & evidence

ORD record
ord-8e7ba6a3986345e0a750e140e1c8cf78
Source dataset
uspto-grants-2010_03
Patent number
US07687637B2

Reaction notes

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