HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-1-butanol → 1-[2-(4-Ethyl-oxazol-2-yl)-ethyl]-3-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-1-butanol | HCID 22129 | — |
| Reactant | 1-Amino-2-butanol | HCID 26107 | — |
| Reactant | 2-(5-Ethyloxazol-2-yl)ethylamine | HCID 11542801 | — |
| Reactant | 2-(4-Ethyl-oxazol-2-yl)-ethylamine | HCID 55285501 | — |
| Reactant | 2-(5-Ethyl-oxazol-2-yl)ethylamine hydrochloride | HCID 66588553 | — |
| Reactant | 1-[2-(5-Ethyl-oxazol-2-yl)-ethyl]-3-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea | HCID 86598448 | — |
| Product | 1-[2-(4-Ethyl-oxazol-2-yl)-ethyl]-3-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea | HCID 86598449 | — |
Reaction Steps
The title compound is prepared by the same procedure as 1-[2-(5-ethyl-oxazol-2-yl)-ethyl]-3-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea (Example 178) by replacing 2-(5-ethyl-oxazol-2-yl)-ethylamine hydrochloride (step 4) with the hydrochloride salt of 2-(4-ethyl-oxazol-2-yl)-ethylamine. This is prepared by the same procedure as 2-(5-ethyl-oxazol-2-yl)-ethylamine hydrochloride (step 4) by replacing 1-amino-2-butanol (step 1) with 2-amino-1-butanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687637B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-afc46268717d492c97e0c130090e0ab9 |
| Source note | uspto-grants-2010_03 |