HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-2-propanol → 1-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-[2-(5-methyl-oxazol-2-yl)-ethyl]-urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-2-propanol | HCID 4 | — |
| Reactant | 1-Amino-2-butanol | HCID 26107 | — |
| Reactant | 2-(5-Ethyloxazol-2-yl)ethylamine | HCID 11542801 | — |
| Reactant | 2-(5-Methyl-oxazol-2-yl)-ethylamine | HCID 24254980 | — |
| Reactant | 2-(5-Ethyl-oxazol-2-yl)ethylamine hydrochloride | HCID 66588553 | — |
| Reactant | 1-[2-(5-Ethyl-oxazol-2-yl)-ethyl]-3-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea | HCID 86598448 | — |
| Product | 1-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-[2-(5-methyl-oxazol-2-yl)-ethyl]-urea | HCID 86598450 | — |
Reaction Steps
The title compound is prepared by the same procedure as 1-[2-(5-ethyl-oxazol-2-yl)-ethyl]-3-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea (Example 178) by replacing 2-(5-ethyl-oxazol-2-yl)-ethylamine hydrochloride (step 4) with the hydrochloride salt of 2-(5-methyl-oxazol-2-yl)ethylamine. This is prepared by the same procedure as 2-(5-ethyl-oxazol-2-yl)ethylamine hydrochloride (step 4) by replacing 1-amino-2-butanol (step 1) with 1-amino-2-propanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687637B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-53aa52a7c8ec4398b89320e5da3509e1 |
| Source note | uspto-grants-2010_03 |