2-Aminopropanol → 1-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-[2-(4-methyl-oxazol-2-yl)-ethyl]-urea

Participants

Role	Name	HCID	Charge
Reactant	2-Aminopropanol	HCID 5126	—
Reactant	1-Amino-2-butanol	HCID 26107	—
Reactant	2-(5-Ethyloxazol-2-yl)ethylamine	HCID 11542801	—
Reactant	2-(4-Methyl-oxazol-2-yl)-ethylamine	HCID 53628805	—
Reactant	2-(5-Ethyl-oxazol-2-yl)ethylamine hydrochloride	HCID 66588553	—
Reactant	1-[2-(5-Ethyl-oxazol-2-yl)-ethyl]-3-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea	HCID 86598448	—
Product	1-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-3-[2-(4-methyl-oxazol-2-yl)-ethyl]-urea	HCID 86598451	—

Reaction Steps

The title compound is prepared by the same procedure as 1-[2-(5-ethyl-oxazol-2-yl)-ethyl]-3-[5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-urea (Example 178) by replacing 2-(5-ethyl-oxazol-2-yl)-ethylamine hydrochloride (step 4) with the hydrochloride salt of 2-(4-methyl-oxazol-2-yl)ethylamine. This is prepared by the same procedure as 2-(5-ethyl-oxazol-2-yl)-ethylamine hydrochloride (step 4) by replacing 1-amino-2-butanol (step 1) with 2-amino-1-propanol.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07687637B2
Source dataset	uspto-grants-2010_03
ORD ID	ord-e76f3d1e5372438b9fb4809471103700
Source note	uspto-grants-2010_03