2-Methoxybenzylamine → Tert-butyl (2-methoxybenzyl)carbamate

Participants

Reaction Steps

2-Methoxybenzylamine (13.0 g) was dissolved in 80 ml of tetrahydrofuran, and then a solution of 16 g of t-butyl dicarbonate in tetrahydrofuran (20 ml) was added thereto. The mixture was stirred at room temperature for 1 hour, and then the solvent was evaporated. The residue was dissolved in ethyl acetate and successively washed with 1N hydrochloric acid and brine. The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated to give 19.0 g of the title compound.

Provenance & Evidence