Potassium Phosphate, Tribasic → HCID 59219012, compound

Participants

Reaction Conditions

Reaction Steps

230 mg of 3-{[(t-Butoxycarbonyl)amino]methyl}-4-methoxyphenylboronic acid, 197 mg of methyl 2-isopropoxy-5-chlorobenzoate, 30 mg of dichlorobistriphenylphosphinoferrocene nickel and 570 mg of potassium phosphate were dissolved in dioxane, and the mixture was stirred overnight at 95° C. in a nitrogen atmosphere. The reaction mixture was filtered through Celite, and the filtrate was evaporated. The residue was purified by a silica gel column, to give 194 mg of the title compound in the 5:1 hexane-ethyl acetate fraction.

Provenance & Evidence