Hydrochloric Acid → HCID 74010625, compound

Participants

Reaction Steps

9 mg of [3′-(1-Hydroxyiminoethyl)-4′-methoxybiphenyl-3-yl]acetic acid was dissolved in 0.2 mg of tetrahydrofuran, then 25 mg of 4-trifluoromethylbenzyl bromide and 10 mg of sodium hydride were added thereto, and the mixture was stirred at room temperature for 3 days. The reaction mixture was neutralized with 1N hydrochloric acid and then extracted with ethyl acetate. The organic layer was concentrated, and the residue was purified by reverse-phase high performance liquid chromatography to give 5.21 mg of the title compound.

Provenance & Evidence