HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 66961268, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1-([1,1'-Biphenyl]-3-yl)methanamine--hydrogen chloride (1/1) | HCID 17749831 | — |
| Reactant | HCID 66960142 | HCID 66960142 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 66961268 | HCID 66961268 | 20.2% |
Reaction Steps
To a DMF (0.2 mL) solution of (E)-3-[3-cyano-4-(4-methyl-1H-imidazol-1-yl)phenyl]acrylic acid (15 mg) and 3-phenylbenzylamine monohydrochloride (16 mg), TEA (0.007 mL), HOBT (10 mg) and EDC (14 mg) were added one by one, and the reaction mixture was agitated at room temperature overnight. The reaction mixture was concentrated under reduced pressure, the residue was purified by silica gel column chromatography (Carrier: Chromatorex®NH, elution solvent: hexane-ethyl acetate system), and 5 mg of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07687640B2 |
| Source dataset | uspto-grants-2010_03 |
| ORD ID | ord-ede913485ac2494593086e195ee4ba38 |
| Source note | uspto-grants-2010_03 |