Imidazole → Benzaldehyde, 3-fluoro-4-(1H-imidazol-1-yl)-

Participants

Reaction Conditions

Reaction Steps

Potassium carbonate (1.71 g) and imidazole (847 mg) were added to a DMF (20 mL) solution of 3,4-difluorobenzaldehyde (2.0 g). The reaction solution was agitated at 100° C. overnight, water and ethyl acetate were added to the reaction solution, and the organic layer was partitioned. After the obtained organic layer was washed with a saturated saline solution, it was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel chromatography (elution solvent: hexane:ethyl acetate=1:1->ethyl acetate), and 1.11 g of the title compound was obtained. The physical properties of the compound are as follows.

Provenance & Evidence